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erythropoietin (EPO), darbepoetin (dEPO), hypoxia-inducible factor (HIF) stabilizers and activators (e.g

Its proposed mechanisms involve multiple cytoprotective pathways including upregulation of VEGF and growth factors promoting angiogenesis, modulation of the nitric oxide system, activation of the FAK-paxillin pathway for cell migration and tissue repair, interaction with the gut-brain axis affecting dopaminergic and serotonergic systems, and gastroprotective effects against NSAID and alcohol-induced mucosal damage

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Paired t -test was used for the comparison of the pair-wise mean grey values in each group