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second, at the molecular biology level, this involves epigenetic modifications of drug targets, activation of intracellular drug-metabolising enzymes, and abnormal activation of epithelialmesenchymal transition processes and DNA damage repair pathways regulated by key signalling pathways such as the PI3K/AKT and NF-B pathways [126]

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This process is accompanied by the activation of protein kinase C (PKC) and the production of intracellular Ca 2+ influx through IP3 receptors

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