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For the challenging clinical scenario of chronic injuries, which are pathologically characterized by a persistent cycle of inflammation, compromised vascular supply, cellular senescence, and stalled tissue remodeling, the core pharmacological question is profound

Phase I study of continuous-infusion l- S , R -buthionine sulfoximine with intravenous melphalan

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However, the functional characterization of this SNP is unclear, although it may impair the transporter function of glutathione and glucuronide-conjugated substrates (Kim et al., 2010

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Selected References Salehpour S, Sene AA, Saharkhiz N, Sohrabi MR, Moghimian F