10.1016/j.gene.2015.10.009 9
Exendin-4-based GLP-1 receptor agonists The first GLP-1 receptor agonist to be used clinically was the recombinant form of the peptide exendin-4, called exenatide
Furthermore, the registry data of HF patients by European Society of Cardiology (ESC) showed that HFpEF prevalence varied regionally: 18.4% in Southern Europe, 17.6% in Middle East, and 13.0% in Western regions [24]
R.FeelischM.2004 72
Previous studies from our lab have demonstrated the critical role of redox balance in mitochondrial and metabolic health, highlighting YMs ability to modulate hepatic redox potential toward a more reduced state [10]
Factores como la neuropata visceral, la disglucemia aguda, la disbiosis y el sobrecrecimiento bacteriano intestinal tambin contribuyen a los sntomas gastrointestinales en pacientes con diabetes, por lo que se deben considerar mltiples opciones etiolgicas ante sntomas gastrointestinales y no atribuirlos exclusivamente al uso de antidiabticos