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Hope et al

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Patients may consume fewer than 1 liter of total fluid per day during peak GI side effects, well below the general adult adequate intake of approximately 2.7-3.7 liters per day from all sources recommended by the National Academies of Sciences [6]

Similarly, IRE1 dysregulation has been observed in tauopathies, PrD, and HD, highlighting its role in neurotoxicity, whereas ATF6 dysfunction exacerbates protein aggregation and has been linked to FTD and tauopathies

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Mice received an i.p