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10.1097/JCP.0000000000001630 [DOI] [PMC free article] [PubMed] [Google Scholar] 23

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The search employed combinations of the following keywords: N-acetylcysteine, NAC, neuromodulation, synaptic plasticity, neuroprotection, neuroinflammation, oxidative stress, glutathione, neurotransmission, and neurodegeneration

For patients with PAD, we offer minimally invasive treatments such as atherectomy, shockwave angioplasty, balloon angioplasty, and stenting to help restore blood flow

Common adverse effects include gastrointestinal symptoms, particularly nausea (30-50% of patients), vomiting, diarrhea, and constipation

Hadley et al