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Those odds held even after controlling for demographics and other factors, including mood, anxiety, alcohol use disorders, and nicotine dependence

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E-commerce platforms, operating within age-verification requirements, further expand reach by offering greater assortment and subscription-style purchasing for refills or devices

In its 2017 Predictive Toxicology Roadmap, which was published to guide FDAs six product centersincluding CTPin the development and use of new technologies, FDA reiterated its support for the use of NAMs (FDA, 2017)