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Accumulating evidence indicates that CHE should not be regarded as an isolated cerebral disorder, but rather as a multi-organ syndrome arising from complex interactions among the liver, gut, skeletal muscle, and brain [9, 10]

Funding This research was funded by a Wellcome joint investigator award to FR/FMG (106262/Z/14/Z and 106263/Z/14/Z) and a joint MRC programme within the Metabolic Diseases Unit (MRC_MC_UU_12012/3)

Together, this evidence suggests that stress-induced BBB dysfunction associated with combat may have allowed pyridostigmine to penetrate the brain and exert central neurotoxic effects that are characteristic of Gulf War Syndrome

Its stable structure and consistent performance have established it as a widely referenced material in peptide research settings

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