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Metformin targets mitochondrial glycerophosphate dehydrogenase (mGPDH) to control rate of oxidative phosphorylation and growth of thyroid cancer in vitro and in vivo

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It consists of three amino acids: cysteine, glutamic acid, and glycine

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Next, we assessed how HIF-1 levels are modulated by the activity of PI3K/mTOR axis in this setting