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Although preliminary data are encouraging, especially regarding the reduction of inflammation and body weight, open questions remain regarding the effects of these drugs on a longer time scale and on different patient subgroups

We also highlight some of the cellular and animal models currently used in Parkinson research, such rotenone, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and paraquat as inducers, which have many similar features with this disease

Bedtime dosing leverages these metabolic facilitators

Additional inclusion criteria were as follows: capable of reading Dutch (n = 1 excluded) and aged between 18 and 65 years, with a body mass index 34 kg/m 2 , since ARA 290 dosing was not scaled to body size