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The goal is to find the lowest possible dose that elicits the desired effect you're studying, as this will almost always correspond with the lowest incidence of KLOW side effects

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3 Spectrum of SLD and mechanisms of progression to HCC HCC predominantly arises in the setting of chronic liver injury, but the specific insults (metabolic excess, alcohol, or viral infection) converge upon a common pathogenic pathway: dysregulated hepatic metabolism

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roGFP2 reduction/oxidation assay The coding region of roGFP2 64 was cloned into the E.coli expression vector pDEST17, allowing expression roGFP2 fused to a 6xHis-tag

10.1016/j.cellsig.2022.110275 56 FanT.YanQ.HuangJ.AustinS.ChoE.FerrisD.et al (2003)