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What is retatrutide, its dosing schedule, and recommended monitoring when used in clinical trials for weight loss or glycemic control?

Patients with a history of eating disorders require particular caution, as focusing on weight-related drug effects may reinforce unhealthy thought patterns, and certain antidepressants (including bupropion) are contraindicated in this group

Diabetes 63(2):785790 Urva S, Nauck MA, Coskun T, Cui X, Haupt A, Benson C et al (2019) 58-OR: the novel dual GIP and GLP-1 receptor agonist tirzepatide transiently delays gastric emptying similarly to a selective long-acting GLP-1 receptor agonist

Rajiv Kovil notes nearly 50% of his patients could benefit, but only 5% used them due to costgenerics are now changing this

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