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S2), this trend did not rise to the level of statistical significance

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We're excited to welcome Firas Harb, MS to the NexGen stage for a fascinating look inside the laboratory

But McGuire says GIP isnt well understood, and its not clear whether the addition of GIP is driving the increased weight loss or if tirzepatide is just better at activating GLP-1

In skeletal muscle, they downregulate atrophy-associated genes (MuRF1, MAFbx) and upregulate myogenic factors (MyoD, MyoG), thereby improving perfusion and energy metabolism

Falk & Katz-Gerro, 2016)