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PPAR activation suppressed the expression of several genes considered essential in the pathogenesis of OA, including IL-1, inducible nitric oxide synthase, MMP-1, and MMP-13, and prevented the IL-1-induced proteoglycan degradation 38,39

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As with any treatment, one should weigh the pros and cons: PT-141 can spark arousal when needed, but may cause nausea or flushing in the process