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Acknowledgements The authors thank Pandora James for their comments, suggestions and critical reading of the manuscript

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Nutrients 14:3934

While some lean mass loss inevitably occurs during significant weight reduction, the rate is typically 20-25% of total weight lost on tirzepatide compared to 30-40% with diet-only approaches

CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia

The copper interaction anomalies in these proteins contribute to misfolding and aggregation that is linked to neurodegeneration