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[221] [222] The full profile of amphetamine's short-term drug effects in humans is mostly derived through increased cellular communication or neurotransmission of dopamine, [37] serotonin, [37] norepinephrine, [37] epinephrine, [190] histamine, [190] CART peptides, [20] [216] endogenous opioids, [223] [224] [225] adrenocorticotropic hormone, [226] [227] corticosteroids, [226] [227] and glutamate, [195] [212] which it affects through interactions with CART, 5-HT 1A , EAAT3, TAAR1, VMAT1, VMAT2, and possibly other biological targets