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Authors of this review received funding from the European Research Council (ERC) under the European Unions Horizon 2020 research and innovation program (grant agreement No 946192, HUMYCO)(LV), the Interuniversity Special Research Fund (iBOF) from Flanders (grant number 01IB1320, FLEXiGUT)(EM, SDS), the German Research Foundation (HU 730/15 1)(HUH)