B vitamins for NASH: Use methylcobalamin, not cyanocobalamin
Interestingly, SFN-GSH was the 3rd most abundant metabolite detected in this study (after phosphorylcholine and PC(34:1)) based on LC-MS peak height, while SFN adducts with other peptides and amino acids were detected a low levels (Fig 7A and B)
Studies have shown that there is a close relationship between the survival of the mitochondrial GSH pool (mGSH) and that of the cells due to the central role of mitochondria in programmed cell death (apoptosis) as well as important involvement of ROS produced at 90% in mitochondria [17]
While mouse models are invaluable for their low cost, rapid breeding cycle, and genetic tractability, their primary limitation is the failure to spontaneously develop human-like lung disease, which is the main cause of morbidity in patients
Glutathione-S-transferase (GST) is a carrier protein that assists bilirubin uptake into the cytosol and may be implicated in Rotor syndrome
(Source 2) Having sufficient vitamin C in childhood is essential not only for immune health but also for growth and development
