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It improves hydration, preserves oil saturation, and fortifies the skin's membrane

*Correspondence: Wen Zhang, [email protected] These authors share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

39 The weight loss and pathologic inflammation still observed even after removing HDC or H4R signals suggested that histamine- and H4R-independent pathways led to inflammation persistence, likely via the well-described T-cell response in IBD

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