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SGLT2 inhibitor users had the highest rates of hypertension and cardiovascular disease, whereas women prescribed GLP-1R agonists were more likely to be obese or suffer from polycystic ovarian syndrome (PCOS)

Tirzepatide activates both GLP-1 and GIP receptors, creating additional metabolic benefits

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Several animal models and human trials have demonstrated that GLP-1RAs can reduce hepatic steatosis, inflammation, and fibrosis [14,15,16]