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Loren Pickart first isolated this compound from human plasma in 1973 while researching why aged liver tissue could be stimulated to function like younger tissue when exposed to certain blood components

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10.1038/nrmicro.2016.142 Nat Rev Microbiol

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This is an area where the two compounds differ in important ways

Experimental Evaluation of Food-Grade Semi-Refined Carrageenan Toxicity