Abraxane, formulated with albumin-bound nanoparticles and the cancer chemotherapy agent paclitaxel, is a nanomedicine within this size range that has been effective in breast cancer treatments [30,31,32]
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This reaction simultaneously depletes two critically important metabolic cofactors: SAM (the universal methyl donor for hundreds of epigenetic and biosynthetic reactions) and nicotinamide (the precursor for NAD+ biosynthesis via the salvage pathway)
thus, vitamin C supplements are not recommended in people with high iron levels [3, 27]