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In the Phase 3 TRIUMPH-4 trial, nausea was reported by 43%, diarrhea by 33%, and vomiting by 21% of participants

Weight loss medications may help level the playing field because they mimic naturally occurring hormones that support appetite regulation and the breakdown of food into usable energy

Additionally, mitragynine (10 M) inhibited digoxin transport in Caco-2 cell monolayers to the same extent as the clinically relevant P-gp inhibitor quinidine (Rusli et al., 2019)

Other less common side effects may include headaches, dizziness, or tiredness

Nausea, diarrhea, vomiting, and constipation dominated the side effect profile, with incidence increasing at higher doses

What Patients in St