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Interactions with other substances Retatrutide affects gastric emptying, which means it can alter the absorption kinetics of other substances taken orally

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The accumulation of 2-HG triggers the inhibition of -KG-dependent enzymes, such as TET2 (Tet methylcytosine dioxygenase 2) demethylase, and consequently alters gene expression by favoring DNA hypermethylation (Raimondi et al., 2022)

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