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Currently, GLP-1 receptor agonists such as semaglutide and tirzepatide show the strongest clinical evidence for significant weight loss

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These include having had one previous episode of DKA, high HbA 1c , low self-management skills (including omission of insulin therapy), psychiatric disorders, infections, somatic comorbidity, alcohol and drug abuse and less interaction with the healthcare team [211,212,213]

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