( The safety profile of liraglutide in our cohort was consistent with previous pediatric randomized controlled trials (RCTs), with adverse events (AEs) predominantly mild and gastrointestinal in nature, including nausea, vomiting, and diarrhea, reported in 43.6% of participants ( Despite these favorable outcomes, the discontinuation rate during the dose-escalation phase was relatively high (25.6%), mirroring patterns observed in other pediatric liraglutide trials where treatment withdrawal often occurred during the initial weeks, coinciding with peak gastrointestinal symptoms ( A key strength of this study lies in its conduct within a publicly funded healthcare system, entirely independent of pharmaceutical industry sponsorship, thereby enhancing both methodological rigor and external validity
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Weight loss plateaus happen with both orforglipron and tirzepatide
When a comprehensive program is not available, the new guidelines recommend that pediatricians: Try to see children with obesity regularly , do their best to understand and manage all the contributing circumstances, and encourage strategies endorsed by professional organizations, including: drinking fewer sugar-sweetened beverages using recommendations and recipes at myplate.gov getting kids engaged in 60 minutes a day of moderate to vigorous physical activity finding ways to avoid inactivity (sedentary behavior) generally, such as limiting screen time and encouraging active games
Through secure provider messaging, you can discuss any side effects you experience, allowing your clinician to adjust your plan and ensure your treatment is both effective and comfortable
HSAs usually do not require an LMN at the time of purchase, but youre still expected to have clear documentation and receipts to support the expense
