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Muscle loss during GLP-1 weight loss is typically linked to: Low protein intake Large calorie deficits Reduced resistance training Rapid or unstructured weight loss Weight loss always includes a mix of fat and lean mass loss, but research on GLP-1 medications suggests that while fat loss is predominant, some lean mass loss can occur depending on dietary intake and physical activity levels

When you start taking semaglutide for weight loss, your stomach processes food differently than before

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However, these uses are considered off-label, meaning the medication isnt officially approved for these purposes, but doctors may prescribe it based on their medical judgment