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Although the beneficial role of liraglutide in osteoarthritis has long been acknowledged, it was not until recently that a study hypothesized this GLP-1RA mediated macrophage transition to an M2 anti-inflammatory phenotype, inhibiting pro-inflammatory cytokine release in a dose-dependent manner ( 2.3.2 Immune cell recruitment inhibition Apart from inflammatory cytokines secretion reduction, inhibited macrophage infiltration and immune cell recruitment also played a vital role in GLP-1RAs anti-inflammatory ability

Similar to the FISH results, GLP-1R-immunoreactive (IR) elements were observed primarily in the gray matter (Fig

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Further, another inflammatory pathway marker transcription factor, nuclear factor kappa B (NF-B) activity has been shown to be increased in the brains of AD patients (Hong, 2017)

doi: 10.1016/j.diabres.2020.108532