REDEFINE 2 (Phase 3a, NEJM 2025) Davies et al., n=1,206, 68 weeks, T2D + BMI 27
Oral administration results in rapid degradation by gastric acid and hepatic first-pass metabolism, rendering the compounds inactive before reaching systemic circulation
Its unique amino acid sequence contributes to its classification as a stable gastric pentadecapeptide, allowing it to remain intact even in the challenging environment of human gastric juice
Lyophilized (Powder) 28C (3646F) Refrigerator
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Its selective biochemical profile and favorable safety characteristics make it suitable for advanced studies on NAD+ metabolism, mitochondrial function, and metabolic health
