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Once damaged by oxidative stress, neurons may not be able to repair or replace themselves effectively, leading to long-term functional deficits

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Stem Cells 35, 97105

Key challenges for clinical translation include the lack of consistent benefit, as large RCTs and systematic meta-analyses have failed to demonstrate efficacy of prebiotics/probiotics in ICU patients despite encouraging signals in individual studies (Lee et al., 2023)

GLP-1 (1 nmol/l) raised cAMP levels by about 40%, whereas the triagonist did not significantly increase cAMP above baseline, suggesting that Gs signalling may not be the primary pathway mediating triagonist-induced GSIS

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