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doi: 10.1016/b978-0-12-420117-0.00008-6 131 HasegawaYTakanoTMiyauchiAMatsuzukaFYoshidaHKumaKet al

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In particular, there are several mouse models with loss-of-function mutations in signaling through the GH/IGF-1 pathway which have revealed an extension in the animals lifespan

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