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It reduces oxidative and nitrosative stress and minimizes inflammation by blocking inflammatory mediator release, adhesion molecule expression, the recruitment and infiltration of immune cells into the organ and increases the percentage of alternatively activated macrophages (M2) that support the resolution of inflammation [86,87,89,91]

doi:10.1111/1750-3841.12263 87

Relaxin-2, a peptide hormone, has demonstrated the ability to restore range of motion and eliminate capsular fibrosis in mouse models of shoulder arthrofibrosis, making it perhaps the most specifically relevant peptide for this condition

10.1016/j.cell.2016.10.043 Cell

Zhao, J., Goldberg, J., Bremner, J