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As such, the smoking epidemic is having a huge impact on the world population and on the individual risk of transitioning to the worst possible health condition, i.e

This is why many doctors wont do certain operations on patients unless they stop smoking

Table 2 reports other exposure levels)

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"Spatial, temporal, and demographic patterns in prevalence of chewing tobacco use in 204 countries and territories, 19902019: a systematic analysis from the Global Burden of Disease Study 2019"

Most reported cases were in the advanced stage and had full-blown malignancies, indicating that individuals in rural areas do not seek medical care until the lesions become symptomatic or reach a significant size