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European Journal of Nutrition , 54(2):251263

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These stiff gels activate the mechanosensitive ion channel (MIC) TRPV4, which upregulates the activity of the phatidylinositol 3-kinase(PI3k)/Akt pathway, triggering the expression of heat shock protein-(HSP-) 70, which protects against stress-induced cell death [119]

Thats changing for sure, as companies realize the benefits of leveraging what the CRO can offer beyond just a pair of hands. The shift pulls CROs into discovery earlier, including tasks once kept in-house

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