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153,154 Studies have shown that activating GLP-1R leads to a decrease in pro-inflammatory cytokines such as interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-) in adipose tissue, revealing a systemic anti-inflammatory impact

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[DOI] [PMC free article] [PubMed] [Google Scholar] 45.National Guideline Centre (UK), Identifying and Diagnosing ME/CFS: Myalgic Encephalomyelitis (or Encephalopathy)/Chronic Fatigue Syndrome: Diagnosis and Management: Evidence Review D (National Institute for Health and Care Excellence (NICE, 2021)

That gap can reflect: How an individual metabolizes the drug How their satiety signals register How their brain integrates those signals with behavior Genetics and Metabolism: Why Some Bodies Resist Appetite Suppression Genetic variation also shapes this response