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Together, these data support the data presented here suggesting that inhibition of oxidative phosphorylation is a potential mechanism underlying metformin-mediated radiosensitisation in CRC

doi: 10.1172/JCI148550 222 GrossMIDemoSDDennisonJBChenLChernov-RoganTGoyalBet al

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As these free radicals accumulate they begin to overwhelm the bodys ability to safely stabilize them which results in oxidative stress, or damage

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