Moreover, drugs may improve cognitive function without altering A levels, which is in agreement with reports suggesting that the clinical phenotype is not always closely related with the A plaque numbers or load in postmortem AD brains (Aizenstein et al., A frameshift mutation in the ubB (ubiquitin) gene (UBB+1) selectively expressed in brain was associated with increases in neurofibrillary tangles and plaques in AD, Picks disease and Downs syndrome patients, but was not found in the healthy young population, which suggests a link between the UPS and AD pathogenesis (van Leeuwen et al., 1998, 2006)
Ferroptosis is regulated by GPX4, an enzyme that reduces lipid hydroperoxides within biological membranes 26
The importance of glutathione in tumor metabolism and particularly in resistance mechanisms has been widely studied during the last decades
doi: 10.1111/J.0954-6820.1968.TB02452.X
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Chen S, Cao Z, Nandi A et al (2024) The global macroeconomic burden of Alzheimers disease and other dementias: estimates and projections for 152 countries or territories
