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Additionally, total T3 concentrations may be mildly increased [66], suggesting an adaptive enhancement of peripheral T4-to-T3 conversion to attenuate fat accumulation via elevated energy expenditure [67]

In conclusion, these results indicate that SAC exerts its therapeutic effects in UC by suppressing inflammation and preserving intestinal barrier function

(2023) Triple G Protein-Coupled Receptor Agonist Retatrutide for Obesity N Engl J Med 389(6):514-526