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J Cell Physiol 233:93549364 Pan LF et al (2016) The toll-like receptor 4 antagonist transforming growth factor--activated kinase(TAK)-242 attenuates taurocholate-induced oxidative stress through regulating mitochondrial function in mice pancreatic acinar cells

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Specifically, in the absence of an orthosteric ligand, compound 2 displayed a strong partial agonism in cAMP response (80% Emax of GLP-1), a weak partial agonism in pERK1/2 and no detectable calcium mobilization response 29,30

However, what has remained largely unchanged in this time period is how long these aesthetic results last