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Its binding constant (pKa 16.44) is similar to albumin's copper transport site (log = 16.2), allowing GHK to exchange copper with albumin for intracellular delivery.[3] Discovery and design rationale GHK was first identified in 1973 in fractions of human plasma that promoted survival of liver cells in culture

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NAD+ effects are reported over weeks to months of consistent supplementation

Rizzo et al

Metz W, Forssmann WG