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Together these modifications reduce IGFBP binding affinity by approximately 1,000-fold compared to native IGF-1 while preserving IGF-1 receptor (IGF1R) binding

O., Mett J., and Hartmann T., The Impact of Vitamin E and Other FatSoluble Vitamins on Alzheimer's Disease, International Journal of Molecular Sciences 17 (2016): 1785, 10.3390/ijms17111785