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In the search for facial rejuvenation, there is a current trend to replenish volume with the use of fillers

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The activation of the Wnt/-catenin pathway is a key driver in conferring a stemness phenotype on senescent cells (6, 7, 35)

Once the drugs are approved for use, they must be monitored carefully for any new adverse events and to ensure they continue to be effective at controlling diabetes over time [42]

In addition, glutathione- S -transferase and glucose-6-phosphate dehydrogenase help in the detoxification of ROS by decreasing peroxide levels or maintaining a steady supply of metabolic intermediates like GSH and nicotinamide adenine dinucleotide-phosphate (NADPH) necessary for optimum functioning of the primary antioxidant enzymes (Vendemiale et al