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Combination with Metformin or Metformin with Sulfonylurea In a 26-week, double-blind trial (Trial 3, NCT02607865), 1864 adult patients with type 2 mellitus diabetes on metformin alone or metformin with sulfonylurea were randomized to RYBELSUS 3 mg, RYBELSUS 7 mg, RYBELSUS 14 mg or sitagliptin 100 mg once daily

Shapsis explains that how and why semaglutide is prescribed matters just as much as the drug itself

Depending on how the patient tolerates side effects, the dose can be increased up to 2.4 mg per week, which is the recommended maintenance dose for Wegovy

For patients with established cardiovascular disease or increased risk factors, both medications offer meaningful protection against serious cardiovascular events including heart attack and cardiovascular death

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