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\n\n\n\n The compounds multimechanistic nature also makes it challenging to evaluate through conventional clinical trial frameworks, which are typically designed around single-mechanism drugs with well-defined target receptors and predictable dose-response relationships

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the scopolamine preparation that was employed is a widely accepted animal model of the spatial memory dysfunction and produces deficits reminiscent of those observed in early to middle stage Alzheimer's disease patients (Fisher et al., 2003)

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This intermediate genotype may be associated with moderately altered activity-dependent release of BDNF compared with the general population